6. The little horn waxed great even to the host of heaven. Rome did this also. The host of heaven, when used in a symbolic sense in reference to events transpiring upon the earth, must denote persons of illustrious character or exalted position. The great red dragon (Revelation 12:4) is said to have cast down a third part of the stars of heaven to the ground. The dragon is there interpreted to symbolize pagan Rome, and the stars it cast to the ground were Jewish rulers. Evidently it is the same power and the same work that is here brought to view, which again makes it necessary to apply this growing horn to Rome.
7. The little horn magnified himself even to the Prince of the host. Rome alone did this. In the interpretation (verse 25) this is called standing up against the Prince of princes. How clear an allusion to the crucifixion of our Lord under the jurisdiction of the Romans.
8. By the little horn the daily sacrifice was taken away. This little horn must be understood to symbolize Rome in its entire history including its two phases, pagan and papal. These two phases are elsewhere spoken of as the “daily” (sacrifice is a supplied word) and the “transgression of desolation;” the daily (desolation) signifying the pagan form, and the transgression of desolation, the papal. (See on verse 13.) In the actions ascribed to this power, sometimes one form is spoken of, sometimes the other. “By him” (the papal form) “the daily” (the pagan form) “was taken away.” Pagan Rome was remodeled into papal Rome. And the place of his sanctuary, or worship, the city of Rome, was cast down. The seat of government was removed by Constantine in A.D.330 to Constantinople. This same transaction is brought to view in Revelation 13:2, where it is said that the dragon, pagan Rome, gave to the beast, papal Rome, his seat, the city of Rome. DAR1909 176.6
9. A host was given him (the little horn) against the daily. The barbarians that subverted the Roman empire in the changes, attritions, and transformations of those times, became converts to the Catholic faith, and the instruments of the dethronement of their former religion. Though conquering Rome politically, they were themselves vanquished religiously by the theology of Rome, and became the perpetrators of the same empire in another phase. And this was brought about by reason of “transgression;” that is, by the working of the mystery of iniquity. The papacy is the most cunningly contrived, false ecclesiastical system ever devised; and it may be called a system of iniquity because it has committed its abominations and practiced its orgies of superstition in the garb, and under the pretense, of pure and undefiled religion.
10. The little horn cast the truth to the ground, and practiced and prospered. This describes, in few words, the work and career of the papacy. The truth is by it hideously caricatured; it is loaded with traditions; it is turned into mummery and superstition; it is cast down and obscured.
And this antichristian power has “practiced,” - practiced its deceptions upon the people, practiced its schemes of cunning to carry out its own ends and aggrandize its own power.
And it has “prospered.” It has made war with the saints, and prevailed against them. It has run its alloted career, and is soon to be broken without hand, to be given to the burning flame, and to perish in the consuming glories of the second appearing of our Lord.
Rome meets all the specifications of the prophecy. No other power does meet them. Hence Rome, and no other, is the power in question. And while the descriptions given in the word of God of the character of this monstrous system are fully met, the prophecies of its baleful history have been most strikingly and accurately fulfilled. --Thoughts on Daniel and Revelation, pp. 176, 177 (1909)